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Probing the Interactions of Intrinsically Disordered Proteins Using Nanoparticle Tags

Stive Pregent,* ,†,‡ Amir Lichtenstein, ‡ Ram Avinery, † Adi Laser-Azogui, † Fernando Patolsky, ‡,§ and Roy Beck* ,†,‡

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March 30, 2015

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Abstract

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The structural plasticity of intrinsically disordered proteins serves as a rich area for scientific inquiry. Such
proteins lack afix three-dimensional structure but can interact with multiple partners through numerous weak bonds.Nevertheless, this intrinsic plasticity possesses a challenging
hurdle in their characterization. We underpin the intermolecular interactions between intrinsically disordered neurofilaments in various hydrated conditions, using grafted gold nanoparticle (NP) tags. Beyond its biological significance, this approach can be applied to modify the surface interaction of
NPs for the creation of future tunable“smart” hybrid biomaterials.

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