Cancer Diagnosis by Metabolic Activity

Cancer Diagnosis by Monitoring and Analyzing the Metabolic Activity Profiles of Human Peripheral Blood Mononuclear Cells

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Our research explores the metabolic activity of the immune system as a potential diagnostic tool for cancer detection and staging. ‘ImmunoMetaboDiagnostics’, a high-throughput, simple blood test of human peripheral blood mononuclear cells (hPBMCs) was pioneered by our group, and is currently under clinical investigation. A wide spectrum of metabolic activity (MA) rate profiles, in response to increasing concentrations of various nutrients and stimulants, is obtained simultaneously during 1 hour in physiological conditions. The MA measurements are recorded by real-time monitoring of extracellular media acidification.

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Effective explorative analysis of the high throughput MA test requires data mining tools, which are implemented for comparative examination of the many accumulating wide-spectrum MA records.

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In the near future, we wish to expand the clinical research plan in validation studies focused on the application of our proposed ImmunoMetaboDiagnostic approach in the diagnosis of blood cancers, auto-immune diseases and infectious diseases, as well as for follow-up of disease treatment and immunotherapy-guiding tool.